| Standings | P | W | D | L | GD | PTS | |
|---|---|---|---|---|---|---|---|
| 1 | Louisville City | 30 | 22 | 7 | 1 | 37 | 73 |
| 2 | Charleston Battery | 30 | 19 | 5 | 6 | 30 | 62 |
| 3 | Tulsa Roughnecks | 30 | 16 | 9 | 5 | 20 | 57 |
| 4 | New Mexico United | 30 | 14 | 6 | 10 | 4 | 48 |
| 5 | Sacramento Republic | 30 | 13 | 9 | 8 | 17 | 48 |
| 6 | North Carolina | 30 | 13 | 6 | 11 | 1 | 45 |
| 7 | Hartford Athletic | 30 | 13 | 5 | 12 | 12 | 44 |
| 8 | Pittsburgh Riverhounds | 30 | 12 | 8 | 10 | 4 | 44 |
| 9 | Loudoun United | 30 | 12 | 6 | 12 | -3 | 42 |
| 10 | El Paso Locomotive | 30 | 10 | 11 | 9 | 2 | 41 |
| 11 | Phoenix Rising | 30 | 9 | 13 | 8 | 0 | 40 |
| 12 | San Antonio | 30 | 11 | 7 | 12 | 1 | 40 |
| 13 | Orange County SC | 30 | 10 | 9 | 11 | -1 | 39 |
| 14 | Rhode Island FC | 30 | 10 | 8 | 12 | 0 | 38 |
| 15 | Colorado Springs | 30 | 10 | 7 | 13 | -12 | 37 |
| 16 | Detroit City | 30 | 9 | 10 | 11 | -2 | 37 |
| 17 | Lexington SC | 30 | 9 | 9 | 12 | -11 | 36 |
| 18 | Indy Eleven | 30 | 10 | 5 | 15 | -8 | 35 |
| 19 | Tampa Bay Rowdies | 30 | 9 | 7 | 14 | -7 | 34 |
| 20 | Oakland Roots SC | 30 | 8 | 8 | 14 | -10 | 32 |
| 21 | Miami FC | 30 | 8 | 6 | 16 | -15 | 30 |
| 22 | Monterey Bay FC | 30 | 7 | 8 | 15 | -18 | 29 |
| 23 | Birmingham Legion | 30 | 5 | 12 | 13 | -14 | 27 |
| 24 | Las Vegas Lights | 30 | 6 | 9 | 15 | -27 | 27 |