| Standings | P | W | D | L | GD | PTS | |
|---|---|---|---|---|---|---|---|
| 1 | Philadelphia Union | 34 | 20 | 6 | 8 | 22 | 66 |
| 2 | FC Cincinnati | 34 | 20 | 5 | 9 | 12 | 65 |
| 3 | Inter Miami CF | 34 | 19 | 8 | 7 | 26 | 65 |
| 4 | San Diego FC | 34 | 19 | 6 | 9 | 23 | 63 |
| 5 | Vancouver Whitecaps | 34 | 18 | 9 | 7 | 28 | 63 |
| 6 | Los Angeles FC | 34 | 17 | 9 | 8 | 25 | 60 |
| 7 | Charlotte FC | 34 | 19 | 2 | 13 | 9 | 59 |
| 8 | Minnesota United | 34 | 16 | 10 | 8 | 17 | 58 |
| 9 | New York City FC | 34 | 17 | 5 | 12 | 6 | 56 |
| 10 | Seattle Sounders | 34 | 15 | 10 | 9 | 10 | 55 |
| 11 | Nashville SC | 34 | 16 | 6 | 12 | 13 | 54 |
| 12 | Columbus Crew | 34 | 14 | 12 | 8 | 4 | 54 |
| 13 | Chicago Fire | 34 | 15 | 8 | 11 | 8 | 53 |
| 14 | Orlando City SC | 34 | 14 | 11 | 9 | 12 | 53 |
| 15 | Austin FC | 34 | 13 | 8 | 13 | -8 | 47 |
| 16 | FC Dallas | 34 | 11 | 11 | 12 | -3 | 44 |
| 17 | Portland Timbers | 34 | 11 | 11 | 12 | -7 | 44 |
| 18 | New York Red Bulls | 34 | 12 | 7 | 15 | 1 | 43 |
| 19 | Real Salt Lake | 34 | 12 | 5 | 17 | -11 | 41 |
| 20 | San Jose Earthquakes | 34 | 11 | 8 | 15 | -3 | 41 |
| 21 | Colorado Rapids | 34 | 11 | 8 | 15 | -12 | 41 |
| 22 | Houston Dynamo | 34 | 9 | 10 | 15 | -13 | 37 |
| 23 | New England Revolution | 34 | 9 | 9 | 16 | -7 | 36 |
| 24 | St. Louis City SC | 34 | 8 | 8 | 18 | -14 | 32 |
| 25 | Toronto FC | 34 | 6 | 14 | 14 | -7 | 32 |
| 26 | Los Angeles Galaxy | 34 | 7 | 9 | 18 | -20 | 30 |
| 27 | Sporting Kansas City | 34 | 7 | 7 | 20 | -24 | 28 |
| 28 | CF Montreal | 34 | 6 | 10 | 18 | -26 | 28 |
| 29 | Atlanta United | 34 | 5 | 13 | 16 | -25 | 28 |
| 30 | DC United | 34 | 5 | 11 | 18 | -36 | 26 |
