| Standings | P | W | D | L | GD | PTS | |
|---|---|---|---|---|---|---|---|
| 1 | Philadelphia Union | 17 | 12 | 4 | 1 | 21 | 40 |
| 2 | FC Cincinnati | 17 | 9 | 3 | 5 | 8 | 30 |
| 3 | Inter Miami CF | 17 | 11 | 3 | 3 | 18 | 36 |
| 4 | San Diego FC | 17 | 7 | 5 | 5 | 8 | 26 |
| 5 | Vancouver Whitecaps | 17 | 10 | 4 | 3 | 22 | 34 |
| 6 | Los Angeles FC | 17 | 11 | 2 | 4 | 18 | 35 |
| 7 | Charlotte FC | 17 | 13 | 1 | 3 | 17 | 40 |
| 8 | Minnesota United | 17 | 8 | 4 | 5 | 9 | 28 |
| 9 | New York City FC | 17 | 11 | 0 | 6 | 7 | 33 |
| 10 | Seattle Sounders | 17 | 10 | 6 | 1 | 18 | 36 |
| 11 | Nashville SC | 17 | 11 | 3 | 3 | 19 | 36 |
| 12 | Columbus Crew | 17 | 9 | 5 | 3 | 9 | 32 |
| 13 | Chicago Fire | 17 | 6 | 6 | 5 | 0 | 24 |
| 14 | Orlando City SC | 17 | 8 | 4 | 5 | 10 | 28 |
| 15 | Austin FC | 17 | 7 | 7 | 3 | 2 | 28 |
| 16 | FC Dallas | 17 | 6 | 3 | 8 | 0 | 21 |
| 17 | Portland Timbers | 17 | 7 | 6 | 4 | -1 | 27 |
| 18 | New York Red Bulls | 17 | 10 | 3 | 4 | 13 | 33 |
| 19 | Real Salt Lake | 17 | 9 | 1 | 7 | 2 | 28 |
| 20 | San Jose Earthquakes | 17 | 5 | 6 | 6 | 5 | 21 |
| 21 | Colorado Rapids | 17 | 8 | 4 | 5 | 4 | 28 |
| 22 | Houston Dynamo | 17 | 5 | 3 | 9 | -10 | 18 |
| 23 | New England Revolution | 17 | 4 | 4 | 9 | -5 | 16 |
| 24 | St. Louis City SC | 17 | 4 | 6 | 7 | -5 | 18 |
| 25 | Toronto FC | 17 | 3 | 7 | 7 | -2 | 16 |
| 26 | Los Angeles Galaxy | 17 | 7 | 2 | 8 | -1 | 23 |
| 27 | Sporting Kansas City | 17 | 4 | 5 | 8 | -7 | 17 |
| 28 | CF Montreal | 17 | 2 | 6 | 9 | -19 | 12 |
| 29 | Atlanta United | 17 | 4 | 8 | 5 | 0 | 20 |
| 30 | DC United | 17 | 2 | 7 | 8 | -18 | 13 |